2025
Amin Javidanbardan, Ziqiao Wang, Abigail Kostic, Ali Behboudi, and Andrew L. Zydney, “Single-pass tangential flow filtration (SPTFF) for continuous mRNA concentration and purification,” Journal of Membrane Science, 719, 123730, 2025. DOI: https://doi.org/10.1016/j.memsci.2025.123730
Cedric Devos, Aniket Udepurkar, Peter Sagmeister, Ariana S. Hodlewsky, Julie Chen, Andrew Hatas, Nicole Ostrovsky, Mushriq Al-Jazrawe, Joy I. Ren, Andy Y. Liu, Richard D. Braatz, and Allan S. Myerson, “Manufacturing mRNA-Loaded Lipid Nanoparticles with Precise Size and Morphology Control,” ACS Nano, 19(38), 33991-34002, 2025. DOI: https://doi.org/10.1021/acsnano.5c09800
Devos, S. Mukherjee, P. Inguva, S. Singh, Y. Wei, S. Mondal, H. Yu, G. Barbastathis, T. Stelzer, R. D. Braatz, and A. S. Myerson. “Impinging jet mixers: A review of their mixing characteristics, performance considerations, and applications,” AIChE Journal, 71(1), e18595, 2025. DOI: https://doi.org/10.1002/aic.18595
E. Botonjic-Sehic, “Novel Integraton of Process Analytical Technologies for Continuous Biomanufacturing,” Pharma’s Almanac, PAO-07-25-CL-05, August 6, 2025. https://www.pharmasalmanac.com/thought-leaders/author/edita-botonjic-sehic-phd
F. Mirasol, “Advancing Biotherapy Production with Continuous Manufacturing,” Biopharm International, March 2025, Volume 38, Issue 2, Pages 19-20. https://www.biopharminternational.com/view/advancing-biotherapy-production-with-continuous-manufacturing
H. Yu, P. Srisuma, D. Devos, J. Wang, A. S. Myerson, and R. D. Braatz. “Hyperspectral imaging techniques for lyophilization: Advances in data-driven modeling strategies and applications.” Advanced Science, e08506, 2025. DOI: https://doi.org/10.1002/advs.202508506
L. Cao, J. Wang, J. Su, Y. Luo, Y. Cao, R. D. Braatz, and B. Gopaluni. “Comprehensive analysis on machine learning approaches for interpretable and stable soft sensors,” IEEE Transactions on Instrument and Measurement, 74:9517217, 2025. DOI: https://doi.org/10.1109/TIM.2025.3556830
Liang Wu and Richard D. Braatz, “A quadratic programming algorithm with O(n3) time complexity”, 2025. DOI: https://doi.org/10.48550/arXiv.2507.04515 (Preprint)
Liang Wu, Wei Xiao, Richard D. Braatz, “EIQP: Execution-time-certified and Infeasibility-detecting QP Solver”, 2025. DOI: https://doi.org/10.48550/arxiv.2502.07738 (Preprint)
M. A. Kanso, S. Singh, A. J. Giacomin, and R. D. Braatz, “Rheology of mRNA-loaded lipid nanodumbbells,” Physics of Fluids, 37, 023109, 2025. DOI: https://doi.org/10.1063/5.0251449
M. C. Pons Royo, T. Arnold, I. P. Rodriguez, N. Ostrovsky, M. Al-Jazrawe, A. Hatas, A. S. Myerson, and R. D. Braatz. “Continuous purification of mRNA by precipitation and sequential TFF,” Separation and Purification Technology, 134837, 2025. DOI: https://doi.org/10.1016/j.seppur.2025.134837
M. C. Pons Royo, T. Arnold, I. P. Rodriguez, N. Ostrovsky, M. Al-Jazrawe, A. Hatas, V. Tenberg, A. S. Myerson, and R. D. Braatz. “Purification of messenger RNA directly from crude IVT using polyethylene glycol and NaCl precipitation,” Process Biochemistry, 156, 263-273, 2025. DOI: https://doi.org/10.1016/j.procbio.2025.06.002
N.M. Stover, S. Ahmadi, J. Rosenfeld, F. Destro, A.S. Myerson, and R.D. Braatz, “Model-based optimization of fed-batch in vitro transcription,” ChemBioChem, e202500485, 2025. DOI: https://doi.org/10.1002/cbic.202500485
P. K. Inguva, S. Mukherjee, P. J. Walker, V. Tenberg, C. Devos, S. Shin, Y. Wu, S. Santra, J. Wang, S. Singh, M. A. Kanso, S. H. Kim, B. L. Trout, M. Z. Bazant, A. S. Myerson, and R. D. Braatz. “Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics,” Biotechnology Advances, 84:108643, 2025. DOI: https://doi.org/10.1016/j.biotechadv.2025.108643
P. Srisuma, G. Barbastathis, and R. D. Braatz. “Simulation-based approach for fast optimal control of a Stefan problem with application to cell therapy,” Automatica, 179, 112398, 2025. DOI: https://doi.org/10.1016/j.automatica.2025.112398
Prakitr Srisuma, George Barbastathis, and Richard D. Braatz, “Probabilistically Robust Uncertainty Analysis and Optimal Control of Continuous Lyophilization Via Polynomial Chaos Theory,” Proceedings of the American Control Conference, July 8-10, 2025. DOI: https://doi.org/10.23919/ACC63710.2025.11107840
Shimin Wang, Yunhong Che, Liang Wu, Martin Guay, and Richard D. Braatz, “Learning-based nonlinear discrete-time observer and its application to output regulation,” Proceedings of the American Control Conference, July 8-10, 2025. DOI: https://doi.org/10.23919/ACC63710.2025.11107943
Soroush Ahmadi, Peter Muller, and Allan S. Myerson, “A new magnesium pyrophosphate hydrate (Mg2P2O7·8 H2O): Structure and properties,” Inorganic Chemistry, 64(37), 18968-18974, 2025. DOI: https://doi.org/10.1021/acs.inorgchem.5c03014
Sunkyu Shin, Cedric Devos, Aniket Pradip Udepurkar, Pavan K. Inguva, Allan S. Myerson, Richard D. Braatz, “Mechanistic modeling of Lipid Nanoparticle (LNP) precipitation via population balance equations (PBEs),” Chemical Engineering Journal, 523, 167786, 2025. DOI: https://doi.org/10.48550/arXiv.2504.10533 (Preprint)
Udepurkar, C. Devos, P. Sagmeister, F. Destro, P. Inguva, S. Ahmadi, E. Boulais, Y. Quan, R. D. Braatz, and A. S. Myerson. “Structure and morphology of lipid nanoparticles for nucleic acid drug delivery: A review,” ACS Nano, 19(23), 21206-21242, 2025. DOI: https://doi.org/10.1021/acsnano.4c18274
W. G. Y. Tan, K. Ganko, S. Santra, M. von Andrian, and R. D. Braatz. “Offset-free stochastic quadratic dynamic matrix control formulations using polynomial chaos expansions,” Control Engineering Practice, 165, 106514, 2025. DOI: https://doi.org/10.1016/j.conengprac.2025.106514
Wallace Tan, Krystian Ganko, and Richard D. Braatz, “Structure-preserving uncertainty quantification and control of population balance models,” Proceedings of the American Control Conference, July 8-10, 2025. DOI: https://doi.org/10.23919/ACC63710.2025.11107683
2023 - 2024
A.B. Cowley and E. Botonijic-Sehic, “Faster, Smaller, Smarter: Intelligent Manufacturing of mRNA Through the Power of Process Analytical Technologies,” Nucleic Acid Insights, December 11, 2024. https://www.insights.bio/nucleic-acid-insights/webinars/662/faster-smaller-smarter-intelligent-manufacturing-of-mrna-through-the-power-of-process-analytical-technologies
E. Botonjic-Sehic, “Process Analytics for the New Era of Continuous RNA Manufacturing”. European Pharmaceutical Review, Issue 1, March 24th, 2024. https://www.europeanpharmaceuticalreview.com/article/217799/process-analytics-for-the-new-era-of-continuous-rna-manufacturing/
Javidanbardan, K. O. Messerian, and A. L. Zydney, “Membrane technology for the purification of RNA and DNA therapeutics,” Trends in Biotechnology, 42(6), 714-727, 2024. DOI: https://doi.org/10.1016/j.tibtech.2023.11.016
L. Wu and R. D. Braatz. “A direct optimization algorithm for input-constrained MPC,” IEEE Transactions on Automatic Control, 70(2), 1366-1373, 2024. DOI: https://doi.org/10.1109/TAC.2024.3463529
Liang Wu, Krystian Ganko, and Richard D. Braatz. “Time-certified input-constrained NMPC via Koopman operator,” IFAC-PapersOnLine, 58(18), 335-340, 2024. DOI: https://doi.org/10.1016/j.ifacol.2024.09.052
N. M. Stover, K. Ganko, and R. D. Braatz. “Mechanistic modeling of in vitro transcription incorporating effects of magnesium pyrophosphate crystallization. Biotechnology and Bioengineering, 121(9), 2636-2647, 2024. DOI: https://doi.org/10.1002/bit.28699
P. Srisuma, G. Barbastathis, and R. D. Braatz. “Mechanistic modeling and analysis of thermal radiation in conventional, microwave-assisted, and hybrid freeze drying for biopharmaceutical manufacturing,” International Journal of Heat and Mass Transfer, 221, 125023, 2024. DOI: https://doi.org/10.1016/j.ijheatmasstransfer.2023.125023
P. Srisuma, G. Barbastathis, and R. D. Braatz. “Real-time estimation of bound water concentration during lyophilization with temperature-based state observers,” International Journal of Pharmaceutics, 665, 124693, 2024. DOI: https://doi.org/10.1016/j.ijpharm.2024.124693
P. Srisuma, G. Barbastathis, and R.D. Braatz. “Simulation-based approach for optimal control of a Stefan problem,” Proceedings of the American Control Conference, 3031-3036, 2024. DOI: https://doi.org/10.23919/ACC60939.2024.10644351
S. Wang, M. Guay, and R. D. Braatz. “Extremum-seeking regulator for a class of nonlinear systems with unknown control direction,” IEEE Transactions on Automatic Control, 69(12), 8931-8937, 2024. DOI: https://doi.org/10.1109/TAC.2024.3426890
S. Wang, M. Guay, Z. Chen, and R. D. Braatz. “A nonparametric learning framework for nonlinear robust output regulation,” IEEE Transactions on Automatic Control, 70(4):2134-2149, 2024. DOI: https://doi.org/10.1109/TAC.2024.3470065
P. Srisuma, G. Barbastathis, and R. D. Braatz. “Analytical solutions for the modeling, optimization, and control of microwave-assisted freeze drying,” Computers & Chemical Engineering, 177:108318, 2023. DOI: https://doi.org/10.1016/j.compchemeng.2023.108318