H. Yu, P. Srisuma, D. Devos, J. Wang, A. S. Myerson, and R. D. Braatz. “Hyperspectral imaging techniques for lyophilization: Advances in data-driven modeling strategies and applications.” Advanced Science, e08506, 2025.
M. C. P. Royo, T. Arnold, I. P. Rodriguez, N. Ostrovsky, M. Al-Jazrawe, A. Hatas, A. S. Myerson, and R. D. Braatz. “Continuous purification of mRNA by precipitation and sequential TFF,” Separation and Purification Technology, 134837, 2025.
W. G. Y. Tan, K. Ganko, S. Santra, M. von Andrian, and R. D. Braatz. “Offset-free stochastic quadratic dynamic matrix control formulations using polynomial chaos expansions,” Control Engineering Practice, 165, 106514, 2025.
P. K. Inguva, S. Mukherjee, P. J. Walker, V. Tenberg, C. Devos, S. Shin, Y. Wu, S. Santra, J. Wang, S. Singh, M. A. Kanso, S. H. Kim, B. L. Trout, M. Z. Bazant, A. S. Myerson, and R. D. Braatz. “Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics,” Biotechnology Advances, 84:108643, 2025.
P. Srisuma, G. Barbastathis, and R. D. Braatz. “Simulation-based approach for fast optimal control of a Stefan problem with application to cell therapy,” Automatica, 179, 112398, 2025.
Amin Javidanbardan, Ziqiao Wang, Abigail Kostic, Ali Behboudi, and Andrew L. Zydney, “Single-pass tangential flow filtration (SPTFF) for continuous mRNA concentration and purification,” Journal of Membrane Science, 719, 123730, 2025.
DOI: https://doi.org/10.1016/j.memsci.2025.123730
Ali Behboudi, Amin Javidanbardan, Ziqiao Wang, Luolin Zhou, and Andrew L. Zydney, “Vibration-assisted ultrafiltration dramatically improves mRNA purification,” Separation and Purification Technology, 363, 132179, 2025.
M. C. Pons Royo, T. Arnold, I. P. Rodriguez, N. Ostrovsky, M. Al-Jazrawe, A. Hatas, V. Tenberg, A. S. Myerson, and R. D. Braatz. “Purification of messenger RNA directly from crude IVT using polyethylene glycol and NaCl precipitation,” Process Biochemistry, 156, 263-273, 2025.
Udepurkar, C. Devos, P. Sagmeister, F. Destro, P. Inguva, S. Ahmadi, E. Boulais, Y. Quan, R. D. Braatz, and A. S. Myerson. “Structure and morphology of lipid nanoparticles for nucleic acid drug delivery: A review,” ACS Nano, 19(23), 21206-21242, 2025.
L. Cao, J. Wang, J. Su, Y. Luo, Y. Cao, R. D. Braatz, and B. Gopaluni. “Comprehensive analysis on machine learning approaches for interpretable and stable soft sensors,” IEEE Transactions on Instrument and Measurement, 74:9517217, 2025.
M. A. Kanso, S. Singh, A. J. Giacomin, and R. D. Braatz, “Rheology of mRNA-loaded lipid nanodumbbells,” Physics of Fluids, 37, 023109, 2025.
DOI: https://doi.org/10.1063/5.0251449
Devos, S. Mukherjee, P. Inguva, S. Singh, Y. Wei, S. Mondal, H. Yu, G. Barbastathis, T. Stelzer, R. D. Braatz, and A. S. Myerson. “Impinging jet mixers: A review of their mixing characteristics, performance considerations, and applications,” AIChE Journal, 71(1), e18595, 2025.
DOI: https://doi.org/10.1002/aic.18595
S. Wang, M. Guay, Z. Chen, and R. D. Braatz. “A nonparametric learning framework for nonlinear robust output regulation,” IEEE Transactions on Automatic Control, 70(4):2134-2149, 2024.
L. Wu and R. D. Braatz. “A direct optimization algorithm for input-constrained MPC,” IEEE Transactions on Automatic Control, 70(2), 1366-1373, 2024.
P. Srisuma, G. Barbastathis, and R. D. Braatz. “Real-time estimation of bound water concentration during lyophilization with temperature-based state observers,” International Journal of Pharmaceutics, 665, 124693, 2024.
DOI: https://doi.org/10.1016/j.ijpharm.2024.124693
Javidanbardan, K. O. Messerian, and A. L. Zydney, “Membrane technology for the purification of RNA and DNA therapeutics,” Trends in Biotechnology, 42(6), 714-727, 2024.
DOI: https://doi.org/10.1016/j.tibtech.2023.11.016
S. Wang, M. Guay, and R. D. Braatz. “Extremum-seeking regulator for a class of nonlinear systems with unknown control direction,” IEEE Transactions on Automatic Control, 69(12), 8931-8937, 2024.
N. M. Stover, K. Ganko, and R. D. Braatz. “Mechanistic modeling of in vitro transcription incorporating effects of magnesium pyrophosphate crystallization. Biotechnology and Bioengineering, 121(9), 2636-2647, 2024.
DOI: https://doi.org/10.1002/bit.28699
P. Srisuma, G. Barbastathis, and R. D. Braatz. “Mechanistic modeling and analysis of thermal radiation in conventional, microwave-assisted, and hybrid freeze drying for biopharmaceutical manufacturing,” International Journal of Heat and Mass Transfer, 221, 125023, 2024.
DOI: https://doi.org/10.1016/j.ijheatmasstransfer.2023.125023
P. Srisuma, G. Barbastathis, and R. D. Braatz. Analytical solutions for the modeling, optimization, and control of microwave-assisted freeze drying. Computers & Chemical Engineering, 177:108318, 2023.
DOI: https://doi.org/10.1016/j.compchemeng.2023.108318